Siah-1/2 Polyclonal Antibody

簡要描述：Siah-1/2 Polyclonal Antibody
宿主: Polyclonal, Rabbit,IgG
反應(yīng)性: Human;Mouse;Rat
應(yīng)用: WB;IHC;IF;ELISA

產(chǎn)品型號： YP-Ab-00522

所屬分類：多克隆抗體

更新時間：2024-11-01

詳細說明：

Siah-1/2 Polyclonal Antibody

抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的?？贵w以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據(jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個抗體的重鏈則決定了它的類或型。

產(chǎn)品詳情

Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.

免疫原詳細信息

The antiserum was produced against synthesized peptide derived from human SIAH1. AA range:181-230

相關(guān)試劑

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

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備注：圖片僅供參考。僅供科研，不可用于臨床。